Sentence examples for mutation was successful from inspiring English sources
Given that the magnitude of fitness effects is higher on average for deleterious mutations than for beneficial ones [ 31], and given that the digital organisms used in our experiment reproduced asexually, the chance that a beneficial mutation was successful critically depended on whether it first appeared on a genetic background free of deleterious mutations.
Genotyping for PIK3CA exon 9 mutations was successful in 488 ERα-positive tumor samples.
As shown in Table 3, all 4 types of mutations could be detected using the pyrosequencing technology (11 of 11, 100%%) (Fig. 1), which demonstrated that the method was reliable for the detection of KRAS mutations in tumors.> Pyrosequence analysis of KRAS codon 12 and 13 mutations was successful for 203 of 204 (99.5 %) ESCC paraffin-embedded tissues.
Consensus mutations have proven effective for increasing stability, but these mutations are successful only about half the time.
EGFR mutation analysis was successful in 136 patients and mutations were identified in 4% (n=5) of the patients.
TP53 mutation analysis was successful in 155 out of 195 (79%) CRCs.
Out of the 226 DNA samples screened for the presence of mutations, genotyping was successful in 205 samples for KRAS (90.8%), 15970.4.4%) for NRAS, 220 for BRAF and 220 for PIK3CA (97.3% in each case) (Table 2).
However, prior to gene expression, it is important to analyze the DNA construct to see whether the introduction of the mutation was indeed successful.
PCR products from ORFs in the region of minimum overlap (NCU00651- NCU00655) were tested for their ability to complement the un-7 mutation and only NCU00651 was successful (Table 2).
In 281/294 (96%) of the samples the two mutation assays were successful in establishing a mutant or wild-type outcome.
Although the present study cannot therefore address exactly how to tune mutation rate parameters on a per family level, it is clear from our results that out pairwise mutation model is successful in improving the detection of remote homologs of β-structural motifs.
