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Interestingly, p53 mutation was strongest as a predictor of disease recurrence, but less strong as a predictor for death.
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Moreover, the association between prophylactic drug use and mutation was stronger for the studies that included multiple isolates than for those that did not.
The negative effect of the mutations was strongest at low glycan substrate concentrations [ 19].
The suppressive effects of the mutation are stronger at lower temperatures, probably because m41 is a temperature-sensitive allele with a stronger phenotype at higher temperatures.
When selection or mutation is strong, the mean and variance of the Gaussian transition density will be biased.
Being able to develop a mutator phenotype accelerated tumorigenesis (Fig. 4B), although the accelerating effect was reduced when selection for additional driver mutations was strong.
Assuming no CpG effect in CpG islands, these comparative results indicate that the influence of CpG→TpG/CpA mutations was strong in intergenic regions and even stronger in exons.
Activating KRAS mutations are strong independent negative predictors of response to such treatment and mutational testing has been included in colorectal cancer practice guidelines.
In other words, if all mutations that a hybridogen carries affect fitness, regardless whether they reside on the sexually or clonally transmitted part of the genome, selection against all newly acquired mutations is strong if mutations interact synergistically, because of the "borrowed" high mutational load on the paternal genome.
Epidermal growth factor receptor (EGFR) mutations are strong determinants of tumor response to EGFR tyrosine kinase inhibitors in non-small cell lung cancers (NSCLCs).
Three sets of data demonstrated that glycolytic mutations are strong dnaE(Ts) suppressors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com