Because the Ser310 alleles are functional, while A40V is not, it is unlikely that the cause of the malfunction of the A40V mutation is solely reduced BicD phosphorylation.
Thus, we can conclude that this single amino acid mutation is solely responsible for the increase in virulence of the QA23ML-3Egg vinus in mice.
Thus, the differences between 3D reconstructions for actin filaments decorated with wild-type smooth muscle S1 and those containing the R403Q mutation are solely due to changes in variability in the entire myosin region and not due to partial decoration.
In order to test whether this mutation is solely responsible for all observed differences in transcript levels of Iogen-M4 and Iogen-M8, we performed transcript analysis of Iogen-M4X.
Theoretically, phylogenetic reconstructions based on different housekeeping genes must result in concordant trees in a clonal population in which accumulation of mutations is solely responsible for genetic diversification.
It is unlikely that these single mutations were solely responsible for SUDEP in these cases, as SUDEP is not universal in Dravet Syndrome, although a higher frequency of SUDEP is well recognised to occur (Sakauchi et al., 2011).
The Mx gene family is among the best characterised ISGs, first identified as antiviral proteins following the observation that the sensitivity of many inbred mouse strains to orthomyxovirus was solely due to mutations within the Mx locus [ 39].
It has been demonstrated that a single amino acid mutation, N194K, in the nonpathogenic RABV vaccine strain SAD B19 was solely responsible for its increased pathogenicity.
"It was solely based on merit".
Thus, the toxicity of FUS mutations may be solely due to their impact on nuclear import [ 6, 13, 17, 22, 26].
