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The number of cases (five) without ATP1A3 mutation was small: none of these cases had documented ECG changes.
However, the study is limited as it was a retrospective analysis and the number of patients with a PIK3CA mutation was small.
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But, unlike the filamentous viruses produced by wild-type (∼ 100 nm wide), the width of the filamentous particles produced by M1 mutation was smaller (Fig. 4C and D).
In male flies null mutation of the p53 gene increased mean life span by +12%95%5% bootstrap CI [4.92-14.50]; log-rank p-value ≈ 0), whereas the effect of heterozygous mutation was smaller, yielding mean life span increases of +5.5%95%5% bootstrap CI [2.15 - 7.53]; log-rank p-value ≈ 0).
The next most common type of mutation is small deletions (defined by HGMD as 20 bp or less), followed by splicing mutations and gross deletions.
If there are few mutations elsewhere in the gene (where they can be determined more reliably) the likelihood of a mismatch in the junction being due to a mutation is small.
The consensus sequence of the population of T7LME_2000 contained 17 mutations in addition to those found in T7 LME_200, indicating that evolution continued but that fitness effects per mutation were small by usual standards of T7 adaptation (Table 3).
This suggests that the size of the haplotype blocks associated with a causative QTL mutation are small compared to the size of the QTL confidence intervals obtained in our F2 segregation analysis.
As long as the fraction of sexually antagonistic alleles generated by mutation is small, our results suggest that sexual selection could still yield net benefits to females, though estimating the precise fraction of mutations that are concordantly selected vs. sexually antagonistic should be a priority.
In the treated participants, G to C mutations were also increased, although the overall number of these mutations was small and the increase was not seen after day 56.
The number of BRAF mutations was small (n=7 8)), and conclusions drawn from this sample size should therefore be regarded with caution.
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