Sentence examples for mutation was reduced from inspiring English sources

This was because the likelihood of a mutator clone hitchhiking to clonal dominance on a selective sweep of a driver mutation was reduced when there were fewer selective sweeps.

The T → G mutation was reduced in strains with deficiency in any of the three SOS polymerases.

Detailed molecular data on breast carcinomas from mutation carriers are shown in Table 2. MMR protein corresponding to the germline mutation was reduced or lost in 13/20 (65%) and MSI was present in 8/23 (35%).

High basal and hypoxia-induced expression of HIF-1α in FTC-133 cells that harbour a phosphatase and tensin homologue (PTEN) mutation was reduced by introduction of wild-type PTEN.

However, PKA phosphorylation of an AQP0 peptide (residues 223 242) harbouring this R233K mutation was reduced by 5.8-fold (n = 3, p < 0.001) when compared to the WT sequence (Fig 4H and I).

In the presence of glutamine, the destabilizing effect of the DKK triple mutation is reduced by about 50% suggesting an involvement of glutamine in the stabilization of the PfPdx1 assembly.

The viability of adults homozygous for the GE24185 mutation is reduced by a third or more, while F2 flies do not survive.

In a genome that is constrained by size (perhaps, as has been suggested, because of the energy requirements associated with flight [ 50, 51]), the opportunity for mutation is reduced and only fission (or intrachromosomal rearrangement such as inversion) can occur.

Interestingly, the pore radius at the level of 9′ was strongly affected by the mutation, being reduced from 2.28±0.06 Å to 1.91±0.03 Å, for GLIC wt and S6′T, respectively (Supplementary Figure S7A).

To support this, we have shown that interferon γ production from cell lines stimulated with peptides containing the K1088R mutation is reduced and that mutant peptides failed to stimulate antigen-specific proliferation in vitro.

Comparing averaged currents recorded between pulse 10 and 20 with currents recorded between pulse 140 and 150, normalized peak current for cells expressing channels with the L858F mutation were reduced by 26% (n = 8; P < 0.05), while the effect of mexiletine on currents recorded from WT controls remained unchanged.