Sentence examples for mutation was realized from inspiring English sources
While a single mutation (K7R or K10R) partially reduces the ubiquitination profile of MAVS (data not shown), MAVS ubiquitination was strongly inhibited when a double mutation was realized (K7R/K10R).
Not all mutations are realized with equal probability; those that are more beneficial are more likely to occur.
Indeed, approximately 20% of melanoma patients treated with the BRAF inhibitors vemurafenib or dabrafenib develop keratoacanthomas and/or squamous cell carcinomas of the skin that can harbor activating RAS mutations (mostly HRAS), suggesting that the oncogenic potential of these RAS mutations is realized specifically in the context of drug treatment [ 6].
The importance of CBS domain was realized by the observation that point mutations in the CBS domain cause several hereditary diseases in humans [ 6].
The euthanasia was realized by cervical dislocation.
Hemorrhage compensation was realized by intraoperative autohemotransfusion.
Current estimates suggest a 17-hr generation time under selection and clones have to reach a much more substantial colony size before the rarer secondary purR or purO mutation could be realized.
This suggests that once the third most common pathways involving single mutations have been realized, the same evolutionary principles can be applied to double mutations starting with double mutations in negative regulators, followed by double mutations in one negative regulator and one promoter mutation.
Moreover it should be realized that P53 mutation occurs at last stage of CC tumorigenesis and is not observed in all neoplastic cells.
In the protein universe, selection is realized through function: mutations leading to loss of function are rarely observed.
The overall procedure of using nucleotide mutation frequencies to estimate codon mutation frequencies was first suggested by Deminoff et al. who argued that adequate statistical power could not be realized if only codon-triplet mutations were analyzed.
