Sentence examples for mutation was proved from inspiring English sources

Though T790M mutation was identified at 2005 [ 83, 84], it is not until 2009 that T790M mutation was proved being identified from plasma DNA in 54% (15 of 28) of patients with prior clinical response to gefitinib/erlotinib, 29% (4 of 14) with prior stable disease, and in 0% (0 of 12) that had primary progressive disease or were untreated with gefitinib/erlotinib [ 19].

The precision of the intended mutation was proven and possible off-target effects caused by the genome editing system were ruled out by genome sequencing of several mutants.

Thus, the p.Asp24Val mutation was proven to be deleterious.

Bizarrely, the underlying mutation was proving difficult to find despite the small size of the region of interest.

This mutation was proven heterozygous in the parents (I-2, I-4, and I-5) of the patients).

The G468A mutation was proven to be an activating mutation by the kinase assay and the transformation assay (Davies et al, 2002).

The PCR product was demonstrated as a 1436 bp amplicon, and the presence of the mutation was proven by four additional bands at 1184, 594, 590 and 252 bp.

The mutation was proven to be causative based on absent expression of the protein in T lymphocytes analyzed by flow cytometry with two anti-XIAP antibodies clones (clone48 BD Biosciences, cloneE-2 Santa Cruz Biotechnology).

Many new mutations were proved to emerge during fulminant hepatitis B in infants, who had been perinatally infected.

If the somatic SDHB mutations are proven to play a role in oxygen homeostasis in PBMCs and leukemic T cells, targeting of the SDH complex might provide new therapeutic tools against infections, leukemia and cancer.

Intriguingly, de novo mutations were proven to be present in three further isolated cases.