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Each mutation was picked at random from many possible alternatives (see 'Phenotypes accessible through mutation' below).
This mutation was picked for our analysis because it has been shown that it significantly lowers gene and protein expression levels (Pan et al., 2008).
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The masks used in mutation are picked up from the pregenerated two 'repositories' of the random binary digits.
To reduce the likelihood of fixing additional mutations during this process, colonies containing the secondary mutation were picked and restreaked as soon as they were visible (approximately 14 hours).
Only a fraction of the many possible mutations are picked up by expanded newborn screening, and precious days are lost while test results are processed.
If two or more of these mutations were picked up by selection and simultaneously started to increase in frequency, at some point they started to interfere with each other, thus preventing the fixation of any allele and the sweep itself.
Actually, the fact that ESX-1 mutations were picked up supports the reliability of our screen.
These mutations were picked up in half (49%) of cases in our study.
Piebald camels probably originated in the eastern Sahara hundreds of years ago from a mutation that was picked up and selected for by local pastoralists who already had a preference for piebald livestock.
Considering the fact that the excess risk of ovarian cancer in FDRs of mutation carriers was picked up in the present study, it does seem justified to draw the conclusion that the risks of prostate cancer and of colorectal cancer up to the age of 79 years in BRCA1 and BRCA2 families are significantly lower than the risk of ovarian cancer in FDRs of BRCA mutation carriers.
Since SKBR3 cells are homozygous for this mutation, the sequence in Figure 7B verifies that a SKBR3 cell was picked from this slide independently.
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CEO of Professional Science Editing for Scientists @ prosciediting.com