Sentence examples for mutation was necessary from inspiring English sources

Wild-type HSV-2 MS (ICP0+) virus was included as a control to verify that the 0ΔNLS mutation was necessary to attenuate the pathogenesis of HSV-2 infection.

It has been proposed that COSMC mutation was necessary to provide the Tn acceptor substrate for ST6GalNAc I to synthesize sTn antigen [ 34].

Transgenic expression of the ZAP-70 skg allele on a ZAP-70 deficient background confirmed that the ZAP-70 mutation was necessary and sufficient for the development of arthritis.

Normal FAP tissue where cells have one APC-allele mutated in germline did not express COL11A1, why we hypothesized that a complete inactivation of the wild-type allele by a second mutation was necessary for the up-regulation of COL11A1.

Thus, the gltA1 mutation was necessary for potentiating the evolution of Cit+ because it converted the citT duplication from a prohibitive step downward into a valley in the fitness landscape into a step in an upward mutational route.

While immuno-histochemical staining for SMARCB1 protein has greatly facilitated the diagnosis of rhabdoid tumor, identification of a mutation is necessary for the ascertainment of the germ-line mutational status.

Mutation is necessary but not sufficient for phenotypic expression and there are no simple phenotype-genotype relationships.

For these, the concepts of penetrance and expressivity operate in ways which accommodate the one-one genetic determinist model where the mutation is necessary and/or sufficient for both the presence of the condition and confounding patterns of phenotypic variability.

However, additional studies involving older healthy family members of LRRK2 PD patients, who carry the mutation, are necessary to validate these findings.

The distance between the cut site and the mutation is necessary because of recision.

This suggests that the Crb1 rd8/rd8 mutation is necessary, but not sufficient for the development of these degenerative features.