Exact(5)
Though the efficiency of mutation was lower compared to pyrE, we observed a frequency of ~1 selD deletion in every 5 colonies tested (~20% mutation frequency) (Table 2).
In general, the likelihood of two individuals sharing the same profile with the exception of a single mutation was lower than the likelihood of a single individual appearing to have two profiles due to a sequencing/scoring error ('stutter' or allelic drop-out).
The prevalence of PfDHFR triple mutation was lower in this study than in children who received IPT with SP+AQ or SP+AS in the two previous trials in the same area [3], [4].
The frequency of the BRAF p.Val600Glu mutation was lower (4.0%) but comparable to the reported frequency range of 4-18% in mCRC without KRAS codon 2 mutations [ 25, 27- 30].
Although the mean non-verbal IQ of the members of the large family carrying FOXP2 mutation was lower than of the unaffected members, non-verbal intellectual impairment could not be considered characteristic of the phenotype associated with this FOXP2 mutation (Lai, et al., 2001).
Similar(55)
Not only are such viruses attenuated, but, because their rate of mutation is lower, they are less able to revert to a less faithful polymerase.
Despite the fact that a percentage of surgical and biopsy specimens that are described as harbouring a single heterozygous mutation is very high (35%), the proportion of cultured cancer cell lines supposedly carrying such a mutation is lower (10%).
In Australia, the prevalence of the mutation is lower in 10 out of 1474 (0.68%) female breast cancer cases and one out of 736 (0.14%) controls (CHEK2 Breast Cancer Case-Control Consortium, 2004).
Data from [ 14]. *The chance of detecting a mutation is lower, because at least 15% of mutations are regulatory (ie they are not in the coding region of the gene that is the area tested), and the genetic screening methods are approximately 80% sensitive if sequencing is not used.
Assuming SI8 30 sites are the least constrained class, the slower X evolution observed at these sites suggests either that these positions are weakly constrained, with more effective purifying selection on the X, or that the rate of mutation is lower on the X chromosome.
The number of stop mutations was lower than the CODDLE predicted proportions.
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