Sentence examples for mutation was localized from inspiring English sources

The region of the mutation was localized to a 22.6 Mb interval on chromosome 15 containing 180 known genes.

The germline mutation was localized on exon 13 of the APC gene (C1660 T; Arg 554 X).

The nl13 mutation was localized between Zv2560 and Zv8353 on chromosome 18 using bulked segregant analysis with SSLPs.

We first sequenced the 333 bp Dam15 allele finding that the amber mutation was localized to the 204th bp of D, converting the 68th CAG codon (glutamine), to an amber translational stop signal (TAG) codon.

Our cellular and biochemical analysis of these four DDR2 mutations showed that these fall into two classes: all previously identified missense mutations cause a trafficking defect with the affected proteins mis-localizing to the ER, while the novel p.E113K-DDR2 p.E113K-DDR2localized in the cell simutation wisd-type DDR2 but is defective in transmembrane signalocalizedto a linand-binding defecthe

Such a hypothesis would be consistent with the point mutation being localized in a portion of the protein previously reported to interact with dynein [12].

For many genetic diseases the genomic interval of a causative mutation is localized using linkage and association studies [18], [19], [20].

The last mutation is localized before the last transmembrane domain.

The gun4 mutation is localized to a porphyrin binding protein GUN4.

This point mutation is localized in a domain that is common in binuclear zinc cluster transcription factors.

A decrease in the density of polymorphic markers indicates the region where the phenotype-causing mutation is localized.