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We suspect that the acquisition of the saeS mutation was facilitated by the increased resistance of sae mutants to environmental stresses such as high temperature, aeration, and the presence of erythromycin, the antibiotic used for the generation of a single cross-over during the deletion of ausA [15].
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Because the accumulation of slightly deleterious mutations is facilitated by an increase in drift, lineages with relatively small effective population sizes (e.g., mammals) tend to have large genomes due to the proliferation of transposable elements and the lengthening of introns (Lynch and Conery 2003; Lynch 2006a).
This was facilitated by a mutation that lead to an upregulation of the glyoxylate shunt [ 23].
Mosaic mutation detection could be facilitated by the increased sensitivity resulting from the high read depth provided by massively parallel sequencing.
Detection of mutations by DNA sequencing can be facilitated by scanning methods to identify amplicons which may have mutations.
However, malignant progression of early lung lesions in the V600EBRAF model can be facilitated by mutations in key genes including depletion of tumour suppressor TRP53 (Dankort et al, 2007) or constitutive activation of β-catenin (Juan et al, 2014), indicating that these early lesions are indeed precursors for adenocarcinomas.
Hence, enzyme recruitment can be facilitated by any mutation that amplifies the cellular concentration of a catalyst to an extent such that a latent function rises to a physiologically relevant level.
Oncogene-independent maintenance of c- myc-induced mammary adenocarcinomas is facilitated by ras mutation, the oncogene-independent maintenance of activated Neu-induced adenocarcinomas and metastases is altered when they are transplanted to a different environment, and p53 heterozygosity promotes oncogene-independent maintenance and recurrence of Wnt1-induced adenocarcinomas.
Identifying spontaneous or induced mutations in genes for allergenic proteins is facilitated by technological advancements in DNA sequence analysis and proteomics.
Differentiating disease causing mutations from irrelevant genetic variants will be facilitated through use of shared data sets on unaffected individuals.
Whitehead et al. propose that selection for such traits could be facilitated by phenotypic mutations (errors of transcription and, especially, translation).
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