Sentence examples for mutation was expressed from inspiring English sources
It is therefore of particular interest that apoE−/− mice fed the same percentage cholesterol as the HC diet used in our study had reduced plaque development when the apoE−/− mutation was expressed in a mouse strain that completely lacks expression of arginase II [34].
We also found that this mutation was expressed at detectable levels.
Full-length human Ran containing the Q69L mutation was expressed from a pPROEx vector as an N-terminally His-tagged protein containing a TEV protease site.
This finding is also supported by a recent publication showing unaltered learning abilities in very young (3 4 months) NEP-deficient mice [12], while it was significantly impaired if human Aβ (containing the Swedish double mutation) was expressed in addition in these knockout mice [13], [31].
The R132H mutation was expressed in sarcoma cells obtained by exposure to 3-methylcholantrene that were injected subcutaneously in the A2.DR1 mice [ 14].
This has not been previously reported; even in studies in which the identical knock-in mutation was expressed in all tissues, prostates were found to be normal.
An example of the latter is shown in Fig. 3, where a human Tau construct containing the FTDP-17-associated V337 M mutation is expressed in all 302 worm neurons via a pan-neuronal C. elegans promoter.
Since this is a knock-in mouse model, each mutation is expressed under the endogenous promoter, and therefore phenotypic differences were not due to differences in insertion sites or differential expression levels.
When variants of IN-V5 carrying each mutation were expressed in 293T cells, levels of the Y15A-V5, K186Q-V5 and LL241,242AA-V5 IN variants were significantly lower than that of WT (Figure S1A).
The P193A mutation is expressed only in the N-terminally extended ADAR1p150 isoform and increases the effect of other AGS mutations in the same protein.
The suggestion that neurons in Plp1tgs are metabolically abnormal may be paradoxical considering that the mutation is expressed in Olgs and not in neurons.
