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It is extremely unlikely that any of the sequence changes that we scored as a "true" mutation was due to a PCR amplification error.
The authors proposed that the DSD observed in 46,XY carriers of the GATA4 mutation was due to a loss-of-function effect on GATA4 in the developing gonad, interfering with its ability to interact with FOG2 and disturbing activation of the AMH promoter together with NR5A1.
In the duplicated (dp) mutant of I. nil, the mutation was due to the rearrangement of genomic structure by the Em/Spm transposable element [ 18].
The loss-of-function of CsGL3 in the mutation was due to the insertion of a 5005-bp activemous, active LTR-RT in the 4th exon of CsGL3.
To test if the suppression by the basic patch mutation was due to an inability of Dot1 to bind or methylate H3K79, we combined rsc2-V457M with either an H3 K79A mutation or dot1 null mutant.
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Her work on the effects of low-dose radiation on female germ-cells mutation in mammals indicated that only a fraction of mutation is due to low-dose environmental radiation.
The oxt6 mutation is due to the disruption of a complex gene (At1g30460) that encodes the Arabidopsis ortholog of the 30-kD subunit of the cleavage and polyadenylation specificity factor (CPSF30) as well as a larger, related 65-kD protein.
Thus, the dementia caused by the Arctic AβPP mutation is due to AD, albeit with unique features of AD neuropathology.
The xprG2 loss-of-function mutation is due to the insertion of two base pairs which causes a frameshift mutation in the ninth codon of the xprG gene.
It is unlikely that the lethality resulting from this mutation is due to the lack of C-domain activity in terms of Ang II production.
In this model (19– 21), the increased frequency of the disease mutation is due to a mutation rate per cell division at that site substantially greater than the genome average.
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