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For samples recruited through EMBRACE, a pathogenic mutation was defined as an established disease-causing mutation under the classification scheme used by Breast Cancer Information Core.
A mutation was defined as a difference between the amino acid sequence of the studied virus and the wild type (HXB2) virus.
A somatic mutation was defined as a site that was consistently called homozygous in all BN cells (with a minimum of six read-coverage BN cells), but had mutant in less than three BC cells.
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Mutation is defined as a sudden change that occurs in the genes of the offspring when compared to that of parent genes during the evolution process.
Another kind of DNA mutation is defined as "copy number variation".
A back mutation is defined as a mutation which increases the fitness of a genotype as in [ 8].
While a mutation is defined as 'any change in the DNA', most work has focused on studying 'Single Nucleotide Variations' (SNVs).
It is important to distinguish the driver mutations from the passenger mutations; a driver mutation is defined as a mutation that is causally implicated in oncogenesis, whereas a passenger mutation is defined as a mutation that has no effect on the fitness of a clone but is present in the same genome with a driver mutation.
A mutation is defined as a permanent change in the nucleotide sequence, while a polymorphism is defined as a variant with a frequency above 1%.
A mutation is defined as an exchange of one gene in a chromosome against a randomly selected new gene from the dataset.
Finally, the environment of neighbouring amino acid residues around a missense mutation is defined as follows: residues are considered to be neighbours of a mutation if they occur within a limited sphere in 3D space.
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