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Reverse transcriptase containing the conservative K65R mutation was capable of limited phosphorolysis, however the nonconservative K65A and K65Q mutations abolished the activity (Fig. 5).

On the other hand, bevirimat-resistant SP1-A1V mutation was capable of rendering viruses resistant to PF-46496.

In the case of Pro91, a single point mutation is capable of strongly slowing down the conformational diffusion along the denaturation coordinate, becoming a barrier-free downhill process above 371 K.

As mutation is capable of introducing diversity in the search procedure, two types of mutation have attracted the researchers - mutation of global best and mutation based on sharing information from neighbors.

Strains reconstructed with just the citT duplication and this dctA* mutation are capable of fully utilizing citrate (i.e., they are Cit++).

These functional assays demonstrate that the mutation is capable of inducing the intracellular production of the second messenger cGMP, which results in intestinal secretion through CFTR.

It's now clear that thousands, perhaps millions, of genetic mutations are capable of triggering cancer.

High pathogenic avian H5N1 influenza A viruses occasionally infect humans, and a most recent study shows that a reassortant H5 HA/H1N1 virus comprising H5 HA (from an H5N1 virus) with four mutations is capable of viral transmission in mammals (Imai et al., 2012).

Despite their negative effects on fitness, deleterious mutations are capable of drifting to fixation in small populations [5] [9].

Like agonists or inverse agonists, activating or inactivating mutations are capable of shifting the equilibrium toward active and inactive conformations, respectively.

Second, that multiple mutations are capable of producing unexpected changes in cellular physiology by connecting previously unrelated pathways to produce new circuits.