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In accordance with the study of Ngo et al., these mutations were predominantly present in ABC-type DLBCL, occurring in 32.5% of ABC DLBCLs as opposed to only 9.5% of GBC DLBCL, and the L265P mutation was by far the most common mutation.
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The biological and clinical significance of this mutation is by no means clarified.
A powerful way to identify more cancer-promoting mutations is by looking at the entire genome of an individual.
In the current study, DNA mutations are by convention generally presented in the former format.
The mutation was confirmed by sequencing.
The correct mutation was confirmed by PCR.
The presence of the desired mutation was confirmed by sequencing.
The threonine to alanine mutation was confirmed by sequencing.
D474N mutation was created by PCR as described [25].
The resulting mutation was confirmed by sequence analysis.
The R217Q mutation was introduced by site-directed mutagenesis.
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