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Mutation was almost universally destabilizing, indicating a general optimization for the wild-type Cys, including van der Waals and H-bond interactions.
And the mutation was almost nonexistent in the African-American population.
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Under natural conditions, a single copy of any mutation is almost always lost.
However, this is most likely due to the imprecision of these estimates (as shown by the wider credible intervals) as in practice the dhps double mutation is almost always accompanied by a high frequency in the dhfr triple mutation.
For the joint modelling, we collapsed the wild-type alleles of the non-synonymous MC4R polymorphisms into one covariate and all mutations into another [20] as each single MC4R mutation is almost a private event.
The frequency of mtDNA mutation is almost the same in noninflammatory and inflammatory regions.
We investigated a series of 1305 gliomas and showed that IDH mutation is almost constant in 1p19q codeleted tumors.
The retention of the wild-type allele in cancer cell lines with a missense TP53 mutation is almost the same as the frequency amongst cancer cell lines with a nonsense mutation.
The frequency of retention of the wild-type allele in cancer cell lines with a missense mutation is almost the same as the frequency amongst cancer cell lines with a nonsense mutation.
Mice carrying this GRdim mutation are almost as effective as wild type (WT) mice in repressing AP-1 and NF-κB-modulated gene transcription, whereas GR-mediated Tat (Tyrosine aminotransferase) mRNA induction is largely abolished [ 21, 22].
Remarkably, in the presence of Su var)2-5 05, the Pc 15 mutation is almost invisible, demonstrating that the HP1a dose is epistatic to that of PC, and once again places HP1a upstream of PC.
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