Sentence examples for mutation variants of from inspiring English sources

Two different strategies were used to generate point mutation variants of cel5A and bgl1, respectively.

One of IndieBio's most exciting startups, Ranomics, has demonstrated a pipeline that systematically generates "all possible mutation variants" of a disease gene and then tests all of the variants in "model organisms" to see which contain functional defects.

In summary, our findings demonstrate that classical but not 'other' mutation variants of EGFR gene are associated with a higher DCR and better TTP; however, EGFR mutational status should not be considered as the only predictor of response to TKIs since disease control with gefitinib has also been observed in patients without EGFR mutations.

Using 10 µM of luciferase substrate and 10 µM H-89, we observed that the signal from RLuc and RLuc8, an eight-point mutation variant of RLuc, in cells was reduced to 50% (±15%) and 54% (±14%) of controls exposed to the vehicle alone, respectively.

Because of the vast size of genetic space, such studies cannot possibly delineate all genetic variants of a virus that might be transmissible after all, there are more than 10 different possible five-mutation variants of any given hemagglutinin (HA), which is more than what can reasonably be assayed experimentally and the vast majority will not facilitate transmissibility.

66 But even before the identification of SNCA mutations, variants of the MAPT (the microtubule associated tau protein) gene, and particularly its H1H1 haplotype, had been consistently shown as a significant risk factor for PD.

For the first time, upper and lower GI polyps, comprising broad histologies, and even polyposis are an important part of the phenotypic spectrum of individuals with pathogenic germline PTEN mutations (variants of unknown significance were excluded from analysis) and a clinical feature signaling the potential of the diagnosis.

In the present study, four patients had both a 'classical' and 'other' mutation variants; three of them achieved SD (Table 3).

Bcat mice are therefore likely to provide a background that is genetically sensitized for the functional detection and confirmation of mutation variants in components of the canonical Wnt/β-catenin pathway.

Female MMTV/ c-MYC transgenic mice expressed the c-MYC proto-oncogene or a more stable point mutation variant (T58A) of the gene under the control of the hormone-responsive MMTV long terminal repeat (LTR) in an FVB/NJ background (Jackson Laboratories, Bar Harbor, ME).

We identified six missense variants in PARK2 gene: one known pathogenic mutation, two variants of uncertain role, and three nonpathogenic changes.