Sentence examples for mutation used to from inspiring English sources

Hence, the simple mutation used to stabilize the enzyme does not recreate the balance of conformational flexibility evolved in the thermophilic protein.

If the target SSTF is one of the SSTFs used to define the population (i.e. state) of the system, then one may not be able to link the epistatic interaction to the population because the population (i.e. state) disappears as a result of the technique (mutation) used to measure it.

Generally, the type of DNA mutation used to split the samples can be any alteration in the gene.

To control for possible pleiotropic effects of the mutation used to eliminate sperm (q785), sperm was introduced to fog-1 q785 fog-1 q785 glp-1 q224ts glp-1 q224tsth wildtype manimalsnd these animals were examined in parallel.

For example, the GTP/GDP-binding-null K1347A mutation used to test the requirement for GTP-dependent activation (Smith et al., 2006) dramatically destabilizes LRRK2 protein, at least in our experiments (Lewis et al., 2007), and are thus a little more difficult to interpret if toxicity is concentration-dependent.

Work with fibroblasts shows, however, that these point mutations can strongly affect cellular function (Calmels et al., 2009; Schmucker et al., 2011), and therefore the mutation used to generate a mouse model with a knock-in, YAC or BAC strategy has to be chosen with caution.

The functional roles of key mutations used to produce KillerRed are discussed, strong chromophore distortions in the bleached state are revealed, and mechanisms for ROS production and self protection are proposed.

FBI also failed to conduct research to "provide a full understanding of the methods and conditions that give rise to genetic mutations used to differentiate between samples of B. anthracis," the report states.

Single point mutations used to generate kinase dead receptors were generated by cyclic mutagenesis PCR as described in [ 64].

(1) Most of the known mutations used to calibrate the system are only weakly associated with the corresponding disease.

Thus, the histopathological and ultrastructural disturbances that we observe in our mouse model are similar to I4895T and Y522S RyR1 mutations used to model human CCD.