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NGS can fully detect all mutation types of target genes and even chromosomal abnormalities [47].
Mutation types of the APC gene in PG carcinomas differed significantly from those in NPG carcinomas.
Furthermore, some reports demonstrated a different prognosis and clinical presentation with respect to the mutation types of the KRAS gene [ 16, 17].
This indicates that our conclusion on the association between the Alu density and mutation types of cancer genes is still valid even when the genes' physical locations relative to the unstable genome regions are considered.
A comprehensive genomic and transcriptomic survey of multiple mutation types of different sizes in FL patients with detailed clinical annotations and long-term follow-up has not been accomplished.
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Thirty-seven mutypesn types out of 30 isolates were identified in the pncA gene, and most of them were point mutations.
Affymetrix U133A expression data was used to define gene expression patterns by mutation, type of mutation, and cancer stage.
Through the rigorous statistical analysis, we observed the hypothesized association between the Alu density and mutation type of cancer genes.
For example, the value of z i is 1 if the mutation type of gene i is "recessive", or 0 if the mutation is "dominant".
The mutation type of codon 54 was seen in 25.0% of Chinese children (n = 48), 21.4% of adults from Hong Kong (n = 196) and 24.6% of European adults (n = 114).
Frameshifts and stop-gained categories comprised the majority of mutation types for both subgenomes (Supplementary Table 10, Supplementary Note 4).
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