Sentence examples for mutation types indicating from inspiring English sources

Hypomethylated Dnmt1−/− mESCs, which had the highest de novo mutation rate, also displayed the widest variety of mutation types, indicating that several different mutational processes may occur in this cell line.

We did not identify any gene showing a statistically significant differential expression in patients with missense mutations compared to other mutation types, indicating that changes due to the specific nature of the mutational status were not found in our study.

Using sequences from the P. trichocarpa reference as an out-group, a survey of the single-base mutation types indicated that C : T changes were the most abundant (38.6%), followed by A : G changes (30.4%), and overall SNPs the ratio of transitions to transversions was 2.23.

Frequencies of each mutation type indicated that most mutation types in any gene are found in only a single genotype in either subgenome (Fig. 5).

Furthermore, the improvements in PFS and PROs observed with afatinib regardless of mutation type indicate that important clinical benefits are achieved with afatinib in all patients with common EGFR mutation-positive NSCLC.

Runx1, mmu-mir-106a-363, Ccnd3, and Flt3, but not Smg6, are also specific for p53 −/− compared to wild-type, indicating that mutation of these genes is selected for in cells that lack the p19ARF-p53 tumor suppression pathway.

The purified Y443F enzyme showed identical CD spectrum and hydrolysis activity for a water-soluble substrate with the wild type, indicating that the mutation had no influence on the structure and the ester bond cleavage activity.

Numbers in boldface type indicate the 9106C>T mutation alleles.

Numbers in boldface type indicate the IVS16-2A>G mutalleleslleles.

Colour coding indicates mutation type.

TYPE indicates the gene type.