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The observed mutation types are in keeping with this.
Associations between PAH-related exposures and selected p53 mutation types are presented in Table 3.
The following mutation types are currently supported: substitutions, inversions, gene conversions, insertions and deletions.
The latter two mutation types are thought to result from endogenous processes (Greenblatt et al. 1994).
The number of patients and mutation types are shown in Supporting information Tables I and II.
Our approaches to distinguishing fixed-difference mutations from heteroplasmic changes for different mutation types are described in the Materials and Methods.
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Evenly distributed 361 mutations covering all mutation types were found in HR50.
Four independent homozygous mutants (KO1-4) with different mutation types were obtained, and all mutations results in premature stop codons (Fig. 3b).
Direct or cloned sequencing of targeted regions showed that, among those T0 plants, the total mutation rate of these two target sites reached 81.5% (Table 2), and two and three independent homozygous mutants with different mutation types were found at target 1 and target 2, respectively (Fig. 4c, h).
Mutation types were different after fixation, with a predominance (92%) of transition mutations.
Interestingly, we found that the prevalent mutation types were not consistent among horse breeds.
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