Through the rigorous statistical analysis, we observed the hypothesized association between the Alu density and mutation type of cancer genes.
Affymetrix U133A expression data was used to define gene expression patterns by mutation, type of mutation, and cancer stage.
For example, the value of z i is 1 if the mutation type of gene i is "recessive", or 0 if the mutation is "dominant".
The mutation type of codon 54 was seen in 25.0% of Chinese children (n = 48), 21.4% of adults from Hong Kong (n = 196) and 24.6% of European adults (n = 114).
Meanwhile, the InDel filtering criteria include: 1) whether the InDel is novel or known to be disease-related; 2) whether the InDel is located in the coding region; 3) the mutation type of the InDel; and 4) the impact of InDel on the protein product.
Melting points of synthetic DNA target with varied percentages (from 0, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95 to 100%) of the mutation type of single insertion relative to the perfect match templates using Indel_3probe.
NGS can fully detect all mutation types of target genes and even chromosomal abnormalities [47].
Mutation types of the APC gene in PG carcinomas differed significantly from those in NPG carcinomas.
Furthermore, some reports demonstrated a different prognosis and clinical presentation with respect to the mutation types of the KRAS gene [ 16, 17].
A comprehensive genomic and transcriptomic survey of multiple mutation types of different sizes in FL patients with detailed clinical annotations and long-term follow-up has not been accomplished.
This indicates that our conclusion on the association between the Alu density and mutation types of cancer genes is still valid even when the genes' physical locations relative to the unstable genome regions are considered.
