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In a 2016 study in eLife, a team led by Erin Conlon, then a Columbia graduate student, showed that the mutation triggered another RNA-binding protein, called hnRNP H, to form similar clumps that disrupted gene expression.
Antibodies in the blood latched onto the standard Texas virus, but modified viruses carrying the F159S mutation triggered a much weaker effect.
Previously we found that the nonsense mutation triggered an increase in upf1 mRNA levels [34].
When the genomic change was located in an encoding region, we used the Mitoanalyzer programme (http://www.cstl.nist) to determine whether the mutation triggered any amino acid change in the polypeptide sequence.
In this study, we found that the nonsense mutation triggered a decrease in cwp1 and cwp2 mRNA levels and there was a reverse correlation between the expression levels of the cwp1/2 and upf1 mRNA.
The wave patterns were due to clonal competition; each new driver mutation triggered clonal expansion and drove the previously resident cells to extinction.
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Dr. Barzilai and his colleagues suspect that the mutation triggers a cascade of changes in the growth-spurring signals in men's bodies, leaving cells less sensitive to low levels of growth hormone.
These results demonstrate for the first time that OPA1 mutation triggers the upregulation of NMDA receptors expression.
More than 200 repeat copies are considered a full mutation, triggering hypermethylation of the CpG island in the promoter region.
Although the D233G mutation triggers only minor changes in the protein structure, these changes significantly compromise thermostability with Δ Tm = −6.8 °C (Table 1 ).
For example, the C153F mutation triggers conformational changes that block acetate product release channels, resulting in only 2% residual catalytic activity.
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