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Table 4 Quality evaluation framework for regional IO data Aberrant KC indicators Mutation Trend outlier IS indicators Total output Consumption Capital formation Labor compensation Inward/outward flow.
Mutation trend analysis and antiviral drug susceptibility profiling of A(H1N1 pdm09 viruses is essential for risk assessment of emergent strains and disease management.
The significant miRNA subdivision with sudden mutation trend would lead to some homologous miRNA genes.
Here we compared the protein sequences of 2009 H1N1pdm strains with those causing other pandemics and the viruses isolated from humans, swines and avians, and then analyzed the mutation trend of the residues at the signature and non-signature positions, which are species- and non-species-associated, respectively, in the proteins of H1N1pdm during the pandemic of 2009.
We then conducted an analysis to gain insight into 1) the mutation trend of the residues at the signature and non-signature positions in the proteins of H1N1pdm during the pandemic of 2009 and 2) the potential roles of the mutated residues in human adaptation and virulence of the 2009 H1N1pdm influenza virus.
Similar(55)
In another words, TFs and their TFBSs have consistent mutation trends in evolution.
When E. paradoxa was used as an outgroup to polarize the direction of mutations the trend was similar but marginally insignificant (Nicaragua, deleterious/total = 0.268; Jamaica, deleterious/total = 0.242; Brazil, deleterious/total = 0.225, χ = 5.27, P = 0.07).
The presence of BRAF mutation had trended to correlate only with younger age of patients, with borderline significance (median, 51.5 vs 56.5 years for BRAF+ vs BRAF−; p = .08) (Table 1).
Both low-grade and high-grade carcinomas harbored mutations, which trended towards increasing frequency with grade (45.5 %, 53.8 % and 66.7 % in Grades 1, 2 and 3 respectively), and with an overall frequency similar to that of gastrointestinal mucinous carcinomas (Additional file 2: Figure S3).
Although this approach is useful to determine the frequency of resistance, the role of environmental mutations, and trends over time, 2 recent Dutch studies indicated that the frequency of resistance may vary considerably between departments or risk groups within the same hospital.
However, in several stratifications, KRAS mutation showed a trend towards significance (P ≤ 0.05).
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