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These results suggest that the main effect observed in the LTP studies shown here are due to the overexpression and aggregation of mutated human APP, though a small contribution by the PS-1 mutation to this impairment cannot be ruled out.
Introduction of a 3-bp substitution mutation to this core sequence (from CTTCCTCA to CTTgtaCA) completely abolished ATF4 activation (Fig. 7D).
Author response: Yes, I agree that it would be possible in principle to add mutation to this.
We concluded that WDR36 plays an important functional role in the retina homeostasis and mutation to this gene can cause devastating retinal damage.
In A. thaliana, mutation to this key domain results in the loss of ABA2 function in the aba2-13 mutant (González-Guzmán et al. 2002).
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Mutations to this nerve network can cause deafness.
Mutations to this gene determine whether a patient will respond to the drug Iressa.
Mutations to this part of Munc13 affected the ability of the calcium channels to open and close.
However, the exact contribution of different cell types and oncogenic mutations to this heterogeneity are not well understood.
Several mutations to this conserved surface disrupted TRIP13 binding in a yeast two-hybrid assay, while retaining MAD2 binding.
Mutations to this region abolish dimerization, prevent protein trafficking to the plasma membrane, and, consequently, ablate channel activity (Tien et al., 2013).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com