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In ET, a restriction of the mutation to the megakaryocytic lineage could lead to underestimation of the mutated cells percentage when analyzing blood DNA.
The goal is to accelerate the virus's already rapid pace of mutation to the point where it produces such an enormous number of errors in its genome that it ceases to pose a threat.
But the imprinted genes carry a serious vulnerability: since they are silenced, a mutation to the other copy can be disastrous.
Olivia and Isabella share the same genetic mutation to the blood-forming cells of the bone marrow, which must have occurred during their time in the womb because neither of their parents was found to have the same mutation.
In comparison, mutation to the non-essential cysteine C336 has no effect.
To improve the search ability of numeric constants, we added numeric mutation to the conventional procedure.
Patients with a familial RB1 mutation should be offered preimplantation genetic diagnosis to avoid passing on the mutation to the next generation [74].
Gene defects occur in a variety of forms, ranging from a simple base pair mutation to the complete absence of a gene.
Before one can rationally design a treatment, it is necessary to understand the pathway from a gene mutation to the phenotype in patients.
To determine the contribution of each mutation to the overall clinical phenotype of the patient, both mutant alleles were engineered into the wild-type NAG cDNA and expressed in Chinese hamster ovary cells.
Alternatively, mutation to the smaller aliphatic amino acid side chains led to a destabilization in the active site structure which was accompanied by increases in the partition ratios associated with abortive complex formation.
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