Sentence examples for mutation to select from inspiring English sources

Evolutionary overachievers, the bacteria "reproduce every 20 minutes, and each time there's an opportunity for mutation, to select out for resistance," said Dr. C. Glenn Mayhall, a specialist in infectious diseases at the University of Texas Medical Branch in Galveston.

Next-generation sequencing (NGS) is commonly used in a clinical setting for diagnostic and prognostic testing of genetic mutations to select optimal targeted therapies.

Another advantage of using the RGEN-RNP system is that designed sgRNAs or crRNAs can be validated for their efficiency for inducing mutations to select the best ones by using the purified Cas9 protein in an in vitro cleavage assay before the actual transfection/injection into cells or embryos is embarked (Sung et al. 2014).

Recently developed methods for genome editing in bacteria take advantage of the introduction of double-strand breaks by I-SceI in a mutation cassette to select for cells in which homologous recombination has healed the break and introduced a desired mutation.

We performed comparative mutation scanning to select amplicons for aberrant DHPLC profiles not shared by the normal controls.

Second, the genetic location of KIT mutation has successfully been used to guide selection of the KIT inhibitor in melanoma, echoing the broader experience of the use of KIT mutation subtype to select kinase inhibitor therapies in GIST (Heinrich et al, 2008).

These chromosome loss events apparently represent the loss of individual chromosomes rather than an overall return to haploidy, as the cells were able to grow on media lacking arginine and thus seemed to have retained the two homologs of the chromosome containing the arg2/arg7 mutations used to select for diploidy (see Methods).

TKIs such as imatinib are reported not to directly induce mutations, but rather to select the mutations by providing a growth advantage to Philadelphia-positive subclones prior to the therapy or to the mutating cells originating in the highly unstable Philadelphia-positive stem cell compartment during TKI treatment [43].

EGFR mutation is used to select patients for small-molecule EGFR inhibitors in non-small-cell lung cancer and KRAS mutation to de-select patients from therapy with anti-EGFR antibodies in advanced colorectal cancer.

Using mutation rates derived from the literature and conservative biological assumptions, we show via mathematical modeling and simulations that phenotypic mutations allow evolution to select for neutral intermediate alleles of a multi-mutation trait, actually selecting for proteins whose exact DNA sequence is not in the organism under selection.

In cattle breeding, it is important to identify carriers of undesired mutations in order to select them out of the population [ 37].