Sentence examples for mutation to establish from inspiring English sources

We also used a model system with MonoMac-6 cells carrying the Flt3-V592A mutotion to establish a mutation-specific real-time PCR approach also for this molecular aberration.

In molecular methods being developed to this end, selectively neutral genetic mutations, such as synonymous single nucleotide polymorphisms (SNPs) and extragenic tandem repeats [2] present advantages over non-neutral mutations to establish relationships between strains.

Within each category, we performed pair-wise crosses between the individual mutations to establish complementation groups (Table 1 and Table S1).

Specifically they studied the microscopic features as well as immunohistochemical and polymerase chain reaction based tests for DNA mismatch repair and PTEN gene mutations to establish a more targeted and cost-effective approach to those patients with hereditary syndromes.

In this report, we used our newly developed inducible tissue-specific mouse model for FoxN1 gain-of-function mutations to establish biologically significant evidence that over- and ectopic-expression of FoxN1 in early life influences immature TEC, T and B cell, and skin epithelial development.

Here we use our mutation data to establish whether regions prone to mutation might exist within the MSV genome.

Given that the mutation is critical to convert the coalescent estimates to biologically informative demographic parameters, a series of analyses were conducted using different mutation rates to establish a confidence interval of coalescent estimates (Fig. 6).

However, for this to work, prospective, long-term iPSC phenotype/clinical phenotype correlation studies would have to be done in a large population of mutation carriers to establish the natural history and prognosis of sarcomeric cardiomyopathies.

Athletes presenting with cardiac symptoms, abnormal physical examinations, an FH of SCD and/or uncommon ECG findings (table 1) were investigated further with a variety of methods, including standard and tissue Doppler echocardiography, 24-h Holter ECG, maximal exercise stress testing, cardiac magnetic resonance (CMR) imaging and genetic mutation analysis to establish a diagnosis.

To identify additional K-Ras mutations, and to establish the relative frequencies of individual K-Ras mutations in human colorectal tumours, we used WAVE analysis followed by direct sequencing to screen the same tumour series for mutations in K-Ras exon 3 and exon 4B, the most common exon 4 splice variant.

Thus, both mutations seem to establish stabilizing patches at the base of the randomized and elongated EF loop.