Sentence examples for mutation to develop from inspiring English sources

Nevirapine has never been a perfect drug; in prolonged use, it can poison the liver and cause rashes, and the virus that causes AIDS only needs to make a single mutation to develop resistance to it.

Indeed, the Pep null allele appears to require a cooperating mutation to develop disease, just as the R620W polymorphism in humans does not act alone.

This observation implies that at least one further molecular mechanism exists that accounts for the inability of individuals carrying this mutation to develop functional adipose tissue.

The enhanced propensity of individuals with the P22L mutation to develop asthma is in line with the observed decreased capacity of IRAK-M with mutations in this region P22A-A23SS mutont) to down-regulate IL-6 expression in macrophages upon TLR2/4 stimulation.

Requiring more mutator mutations to develop a mutator phenotype (increasing M) prevented the evolution of genetic instability as cells had to acquire more intrinsically selectively neutral mutator mutations through genetic drift (Fig. 4A).

Myriad's ambitious aspiration is to leverage its research in genetic mutations to develop drugs for treating cancer and HIV.

We used naturally occurring human mutations to develop two Gs-coupled engineered receptors that respond solely to a synthetic ligand (RASSLs).

However, if wildtype p53 was transiently induced 8 days post-irradiation, circumventing the acute damage response and instead allowing mutations to develop, significant protection from radiation-associated lymphomas was noted as these mice survived 50% longer.

The use of random mutagenesis and exploitation of spontaneous mutations to develop models has been used for many years [ 5].

First pregnancy later in life results in more time having elapsed for mutations to develop, which become potential tumor sites in the developing MG [ 45].

Migration of barley to regions outside its place of origin was accelerated through mutations to develop reduced vernalization requirement and photoperiod insensitivity (Bothmer et al., 2003).