Sentence examples for mutation to cause from inspiring English sources

Both copies of the gene need to contain this particular mutation to cause anemia.

These changes with age may provide the background for a genetic mutation to cause the pathophysiological and immunological events leading to the development of drusen in dry AMD.

However, there are a few rare families in which the D90A mutation acts as a dominant mutation to cause disease in a heterozygous state (30).

The combinations of genetic alterations that cooperate with von Hippel Lindau (VHL) mutation to cause clear cell renal cell carcinoma (ccRCC) remain poorly understood.

These results demonstrate that Lkb1 is a haploinsufficient pancreatic tumor suppressor, and that lack of only 1 allele is sufficient, when combined with Kras mutation, to cause PDAC.

Interestingly, while imprinting disorders are known to originate from these loci, a highly resolved and restricted deletion in the SNORD116 region was identified as the minimal mutation to cause Prader-Willi Syndrome [ 42].

Although Atg7 deletion resulted in increased mitochondrial mutations, there were too few nonsynonymous mutations to cause generalized mitochondrial dysfunction.

This means that both of a person's copies of RPE65 must carry the relevant mutations to cause the disorder.

A3B can also induce genomic DNA mutations to cause cancer.

However, p.Y486D in heterozygous condition needs to combine with some other deleterious mutations to cause clinically CNS-II.

Therefore, it is possible that only Gsdma3 has gain-of-function type mutations to cause dominant skin phenotype.