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Line 7 specifies that each attempt involves only a single mutation, though again the structure of Stylus allows simultaneous mutations conforming to any frequency distribution.
A new neutral macronuclear mutation, though initially in the minority, can increase in frequency and eventually become fixed in a clonal lineage by assortment.
Stories from the City, Stories from the Sea (2000) might just be her most startling mutation, though: here's slick-and-stylish Polly, sophisticated-and-subtle Polly.
This rare gene-disabling mutation, though, is intriguing because it seems to explain something different, a propensity to pile on pounds even while eating what should be a normal amount of food.
Some success maintaining stability with more extreme redesigns suggests a surprising tolerance to mutation, though it often comes at the cost of loss of binding affinity and presumed loop conformation changes.
For instance, many physicians and patients are screening out embryos with a breast cancer mutation, though these genes wouldn't cause symptoms until adulthood and would do so only about 50percentt of the time.
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Some mutations, though, have much higher frequencies than others, for example, p.Gly2019Ser and mutations altering codon Arg1441.
The nonfamilial cases are not thought to be linked to BRCA mutations, though researchers have debated about whether some of them might be.
And they were able to detect 39 of 44 such spontaneous mutations, though with a huge number of false positives.
In addition, adaptation signatures indicate that pandemic H1N1/09 strain possesses multiple human-transmissibility mutations, though not an unusually high number with respect to swine strains that infected humans in the past.
Most mutations were S-cdG → A mutations, though S-cdG → T mutation and deletion of 5′C also occurred.
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