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In case 2, the cooperative lineage expansion case with early mutator mutation, there is no increase in fitness until a subset of oncogenic mutations have been acquired, at which point the fitness increases rapidly and lineage expansion begins.

Sidransky's team suspected that because cellular debris from the bladder sometimes ends up in urine, they might look for the mtDNA mutation there as well; likewise, mutations from neck and head tumors might show up in saliva, and from lung tumors in lung fluid.

Alleles in white flowered types are represented by a restricted set of haplotypes; for the intron 6 splice donor site mutation there are just two haplotypes in the vicinity of the mutation (Fig. S3C).

Depending on the type of mutation there may be different clinical forms of the disease.

And the presence of one of the simple consensus sequences in some locus does not in and of itself guarantee a mutation in that locus, it only increases the likelihood that we will see a mutation there.

In zebrafish, ectopic Wnt11 (a Wnt-PCP pathway ligand) induces ectopic expression of Pax6 and the formation of bigger eyes, whereas, when mutated (silberblick mutation) there is a partial fusion of the eye field, possibly reflecting defects in morphogenetic movements (Cavodeassi et al., 2005; Heisenberg et al., 2000).

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Similar(9)

"With certain BRCA mutations there is an increased risk of pancreatic cancer, prostate cancer," Yamada said.

But by experimenting with mutations there is a strong possibility they'll be able to cultivate hardier plants that can be farmed in northern Western Australia.

Cells become malignant when k cancer-stage mutations have occurred, no matter how many destabilizing mutations there have been.

For all three patients with these mutations there was intrafamilial phenotypic heterogeneity, as well as differences from phenotypes reported in the literature.

The sequence conservation in this surface and the clustering of CACH/VWM mutations there have not been previously identified.

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