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In contrast, all our three patients harboring a non-functional CHEK2 mutation (the two Arg95Ter mutated patients here and our previous patient harboring the 1368InsA) expressed primary resistance to therapy.
Even with only one residue mutation, the two peptides displayed distinct anticancer modes of action.
And it's clear that in people with the most common mutation, the two drugs do work better together than either does on its own.
It is important to distinguish between DNA damage and mutation, the two major types of error in DNA.
Unlike the NS5A mutation, the two 3'NTR mutations have never been observed in viruses rescued in vivo from the wild-type molecular clone, suggesting they may be in fact true compensatory mutations.
In mice in which the F66 transgene was combined with the Mstn null mutation, the two phenotypes appeared to be additive; that is, the quadrupling of muscle mass in F66/Mstn−/− mice resulted from an approximately 73% increase in fiber number and 117% increase in fiber cross-sectional area.
Similar(51)
Despite their effectively identical DNA (in recent years, scientists have shown that even monozygotic twins generally have a small number of unique genetic mutations), the two men have taken contrasting courses and we want to find out why.
In contrast to missense mutations, the two deletions also do not interact with DPP signaling in both genetic screens.
These protein fitness landscapes were compared and used to calculate epistatic interactions between these mutations and the two mutations in the pathway (E104K and G238S).
The S228P mutation separated the two loops in CTD but not those in NTD.
The S228P mutation separated the two interacting loops from each other and allowed water molecules to penetrate into the hydrophobic core.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com