We proposed in our article (Ryan et al., 2013) that axonal injury and subsequent degeneration may account for the thalamic and caudate atrophy that we observed in the presymptomatic mutation carriers.
"The authors convincingly demonstrate that specific behavioral consequences of the Ptchd1 mutation — attention and sleep — arise from an alteration of a specific protein in a specific brain region, the thalamic reticular nucleus.
The thalamic reticular nucleus and schizophrenia.
The thalamic signal is consistent with thalamic involvement in sleep homeostasis.
Crick, F. Function of the thalamic reticular complex: the searchlight hypothesis.
These oscillatory activities are transmitted to the thalamic relay nuclei.
The thalamic function is considered as the tropism mechanism.
Cavdar, S. et al. The pathways connecting the hippocampal formation, the thalamic reuniens nucleus and the thalamic reticular nucleus in the rat.
In animals implanted over the ADn, the thalamic probe was lowered until the first thalamic units could be detected on at least 2 3 shanks.
(a) Proportion of the thalamic RV-eGFP labeled input being derived from the MD.
