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A century and a half later, in a book called Darwin's Dangerous Idea, the philosopher Daniel Dennett called evolution by natural selection acting upon random mutation "the single best idea anyone has ever had", but the proposition of evolutionary change was not new, even in 1859.
After point mutation, the single reading frame changed to two different ORFs.
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The most significant of inactivation was the SUMO1 modification followed by the double lysine 171/196 mutation and the single mutation (Figure 5C).
In the double mutants and a triple mutant, the single mutations were incorporated in various combinations.
Thus, mutation of the single trpm gene in an insect eliminates all TRPM channel function.
It is generally assumed that mutation provides the single source of biological diversity that fuels evolution.
For 11 of these ARSs, mutation of the single predicted ACS eliminated ARS function.
Mutations in genes of Saccharomyces cerevisiae that code for proteins that interact with beta-tubulin were sought by screening for unlinked mutations that fail to complement mutations in the single beta-tubulin-encoding gene (TUB2).
In both sexually and asexually reproducing species, mutations are the single most important source of genetic variation.
Here, we have obtained null mutations in the single Drosophila neurexin gene (dnrx).
We did not identify mutations in the single mixed hepatocellular-cholangiocarcinoma evaluated.
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