Then, for each BAR mutation, the proportions for the different integrations were pooled.
However, for noncoding AT mutations, the proportion of singletons is higher than that of noncoding GC mutations (35.2% vs. 32.8%).
Because barcode tags are part of the mutations, the proportion of an individual barcode reflects the proportion of that barcode-associated mutant in a population.
The suggestion of a shorter induction period of RT-associated breast cancer in patients, who carry an ATM missense mutation, while the proportion of patients with missense variants was similar in CBC and UBC cases, might be attributable to a different spectrum of mutations in those patients who developed CBC.
Similarly, we test each gene to see if it has a significantly higher proportion of truncating mutations than the proportion of truncating mutations observed over all genes.
In the remaining 59.04% exon 2 wild-type patients we detected 15.31% additional RAS mutations and 12.44% BRAF mutations, reducing the proportion of true wild-type patients from 59.04% to 42.66%.
To estimate the DFEs (DFE, i.e., the distribution of the strength of selection acting against new mutations) and the proportion of adaptive substitutions in A. kamchatica, A. halleri, and A. lyrata, we used the likelihood method implemented in the software DoFE 3.013.
For cancer mutations (CSM), the proportion of variants in solvent inaccessible regions is more than that of SVP but less than SVD.
To estimate the distribution of fitness effects of deleterious nonsynonymous mutations and the proportion of sites under positive selection, we used the DFE-α method of Eyre-Walker and Keightley (2009), which uses data on interspecies divergence and the folded site frequency spectra of variants at synonymous and nonsynonymous sites.
There was no difference between the CPSC of Type 1 and Type 2 VHL disease mutations, or in the proportion of mutations which involve interface residues, implying no clear functional difference between missense mutations described in Type 1 and Type 2 VHL diseases.
