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Since TcNPR3 did not show a perfect complementation of the Arabidopsis NPR3 mutation, the possibility remains that other functions of TcNPR3 remain to be found.
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In patients without known MEN1-related germline mutations, the possibility of a casual association between two or more endocrine tumors cannot be excluded and subsequent management may be difficult to plan.
Children and young adults with diabetes and a strong family history of diabetes: testing for HNF1A mutations The possibility of monogenic diabetes should be considered whenever a parent has diabetes even if they are thought to have type 1 or type 2 diabetes.
We also observed a novel mutation at the same codon as the RNF213 founder mutation, suggesting the possibility that other missense mutations at this arginine position may be associated with MMD.
Feelings of guilt with regard to passing on the gene mutation or the possibility of passing on the gene mutation may also be present.
Further work would be needed to deduce the effects of this mutation, but the possibility of generalised defects in the control of gene expression cannot be ruled out.
The greatest effect on muscle mass was observed in offspring of mothers homozygous for the Mstn mutation, raising the possibility that either myostatin itself or a downstream regulator may normally be transferred from the maternal to fetal circulations.
The frequency of this mutation raises the possibility that variants with this alteration could be involved in the development of high grade intraepithelial and invasive disease.
Basal ERCC-1 expression is not related to KRAS mutation, but the possibility that the enzyme might be poorly induced by OXA in mt tumors cannot be excluded.
Even in patients with a MASS phenotype or with isolated ectopia lentis, the presence of an FBN1 mutation indicates the possibility that the phenotypes progress towards MFS during follow-up.
Although additional functional studies are required, our data in relation to the c.250C>T mutation open the possibility that transacting factors binding to de novo created recognition site resulting in formation of aberrant splicing variant is a disease model which may be more widespread than previously recognized as a mechanism causing inherited RD.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com