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To assess whether catalytic properties were affected by mutation, the optimal reaction conditions were determined.
However, in the subgroup with SDHB mutation, the optimal imaging approaches for bone metastases were CT and MRI (96%), bone scintigraphy (95%), and FDG-PET (92%).
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With the ability to identify inherited mutations in BRCA1, prophylactic oophorectomy and other interventions intended to decrease cancer mortality can be offered specifically to women who carry a mutation, but the optimal strategy for decreasing cancer mortality in BRCA1 families has not yet been determined.
However, if there are hypomorphic deleterious mutations present, the optimal level of compensation may be higher than 2-fold.
Evolution is often viewed as an optimization process, in which selection drives the fixation of fitness-increasing mutations until the optimal phenotype that maximizes fitness is reached [ 1- 5].
Increases to the mutation rate beyond the optimal value at mutation selection balance may therefore prove generally undesirable.
By testing three concentrations, our results indicate a lower concentration was sufficient to induce the same number of lethal mutations compared to the optimal dose (Table 1).
5) Even with costs to excess flux, hypomorphic mutations can cause the optimal level of DC to be higher than 2-fold.
Even with costs to excess flux, hypomorphic mutations can cause the optimal level of DC to be higher than 2-fold when the absolute cost of hemizygosity is small.
The ultimate goal of this optimization is to find the optimal mutation strategy for improving productivity.
Consequently, the optimal mutation rate at the stationary state does not necessarely coincide with the optimal mutation rate before mutation-selection equilibrium is reached.
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