(Given one mutation, is the next mutation on the same strand similar?) There were six clones with mutations at only purine or pyrimidine bases on one strand, and six clones with mutations to both purine and pyrimidine bases on the same strand.
A pair of complementary 'codons' that was already captured by the evolving code would then generate (through complementary mutations) the next, "daughter" pair.
Patients with a familial RB1 mutation should be offered preimplantation genetic diagnosis to avoid passing on the mutation to the next generation [74].
Likewise, for mothers with a homoplasmic mutation, any approach that reduces the mutation load, but does not completely eliminate the mutation, will also introduce the possibility of recurrence in future generations, even if the level of mutation in the next generation is <20%.
Mutation of the next residue, Leu89, to Ile (as in Cx26L89I) results in simple polymorphisms without known deleterious effects [56], in agreement with its orientation towards the lipid phase (Figure S2f).
At FPR = 0.05, the accuracy of VAAST 2.0 is 4% higher than MutationTaster, the next best classifier.
If mutant ES cells partially differentiate into germ cells, the founder mice can transmit the mutation to the next generation of mice.
Among the molecules that can be affected by UV, DNA must be highlighted, since the result of one of such reactions can be transmitted as a mutation to the next generation.
Interestingly, the G to A transitional point mutation at the next codon #248 found in CaPA-4 cells was also found in the surgical tissue samples from the adenoma portion as well as from the carcinoma portion of their original carcinoma ex pleomorphic adenoma [ 13].
