Sentence examples for mutation the latter from inspiring English sources

Because there was no restriction enzyme cutting DNA at the site of mutation, the latter primer contained one mismatch nucleotide for producing a site identified by BtsCI enzyme.

Case 6 harboured both a p.P525L FUS mutation and also a TARDBP p.Y374X truncation mutation, the latter of which has been reported once previously in a French Male sporadic ALS patient with an age of onset of 63 years [ 18].

However, although NII in VCP mutations contain VCP protein [ 7, 26] and may superficially resemble those in FTLD cases with PGRN mutation, the latter do not contain VCP protein [ 28].

The HBG2 g.-109G>T HBG2 g.-109G>Tound both in heterozygosity as well as in comutationeterozygosity wash the HBG2:g.-158C>T (XmnI) polymorphism and the silent HBB:g.-101C>T β-thalassemia mutation, the latter being one ofound most common Hbothutatinn leading to β-theterozygositythe Hellenic populasion [ 20, 21].

These expectations were tested under all three available mutation models: the infinite alleles model (IAM), the stepwise mutation model (SMM) and the two-phased model (TPM) of mutation, the latter of which is thought to best fit microsatellite data [ 62] and recent bottleneck events [ 64].

We hypothesize that endometriosis is induced by a combination of abnormal genetic and/or epigenetic mutations: the latter pave the way for pathological changes which become irreversible, and according to the "epigenetic landscape" theory, this proceeds to the typical clinical manifestations.

We investigated 1053 untreated HIV-1 infected South African individuals from Bloemfontein and Durban, and found that viral fitness was greater in patients with advanced disease with examples of both viral compensatory mutations and of reduction in escape mutations, the latter possibly due to 'immune relaxation'.

For many mtDNA mutations the latter information is not available.

Clearly, a first-step mutation is necessary for the development of subsequent mutations, the latter of which result in MICs that fall within the nonsusceptible category.

This pathway, in turn, is involved in downstream effects of RET/PTC rearrangements, RAS and BRAF mutations, the latter being most frequently verifiable in PTC.

Mutations can be inherited from parents (germline mutations) or acquired over the life of an individual (somatic mutations), the latter being the principal driver of human diseases like cancer.