Sentence examples for mutation the first from inspiring English sources

Two years after identifying the V617F mutation, the first specific JAK2 inhibitors were designed.

For detection of the G428A nonsense mutation, the first PCR was performed under the same primers and conditions as in the first PCR for detection of the C357T mutation.

In the absence of mutation, the first term determines the loss in fitness due to hemizygosity and the reduction in fitness depends only on the number of steps in the pathway.

Site-directed mutagenesis was carried out to produce cDNA corresponding to the deletion of the E50K mutation, the first leucine zipper (1st LZ del), deletion of the second leucine zipper (2nd LZ del) and the H489R mutation.

For the detection of the C357T mutation, the first PCR amplification with the primers Se-F (5′-CTC GAA TTC GGG CCT CCA TCT CCC AGC TAA C-3′) and Se-R (5′-CTC AAG CTT GCT TCT CAT GCC CGG GCA CTC-3′) was performed [ 6].

For the T1067A mutation, the first PCR with the primers [ 4] Le-F (5′-CTC CCG ACA GGA CAC CAC TCC CA-3′) and Le-R (5′-CTC AAG CTT CGT GCC GTG ATG ATC TCT CTG CAC-3′) was carried out in the same PCR buffer as in the PCR for detection of the G508A mutation.

When the variance is small, the mutation (the third term) is dominant, and it increases the trait variance.

Researchers were rather on a quest for the opposite situation, where one crippling mutation is rescued by a second, intragenic, suppressor mutation, the second restoring the function lost due to the first mutation [ 19, 20].

Progression to frank and active disease would require a second somatic mutation (the second "hit") in the remaining allele in the affected tissue type.

Plasmid M1 has a single point mutation; the second 'T' in the HMG domain-binding region was substituted with an 'A'.

The T294M mutation is the first mutation to be shown to selectively abolish the ability of MgADP to stimulate channel activity in the presence of MgATP.