Sentence examples for mutation the expression from inspiring English sources

Owing to the double mutation, the expression level increased by 6-fold (Bmax=311 pmol/mg) in the membrane fraction of Pichia pastoris.

Indeed, in the strain without mutation, the expression threshold necessary to excision is very low.

In contrast, in nine tumours with a PDGFRA mutation and one tumour with a KIT mutation, the expression of PDGFRA was ≤1.32 a.u., while in the remaining GISTs with KIT/PDGFRA mutations, it was ≤0.84 a.u. One tumour with a PDGFRA mutation exhibited overexpression of both KIT and PDGFRA.

Even though the ligand-binding function was abolished by these two mutations, the expression of these mutants was normal at the protein level.

In order to identify additional molecular changes associated with the presence of β-galactosidase mutations, the expression of canine lysosomal multienzyme complex components in GLB1+/+, GLB1+/− and GLB1−/− fibroblasts was investigated by quantitative RT-PCR, Western blot and enzymatic assays.

Among the 12 cell lines with PTEN mutations, the expression of PTEN was observed in the HEC-116, HEC-88, HEC-151, and HEC-251 cell lines.

It has been shown that genome-wide expression profiling could reveal candidate genes responsible for mutant phenotypes, assuming that the mutation affects the expression of the target gene (Dybbs et al. 2005).

Combining the status of the Kirsten rat sarcoma viral oncogene homolog (KRAS) G12D (35G>A) mutation with the expression profiles of 69 genes associated with clinical prognosis classified the adenocarcinoma cells into four groups with different gene expression patterns.

Basonuclin-null mutation affected the expression of three of the seven v-rDNAs.

Nevertheless, our data strongly suggest that basonuclin-null mutation impairs the expression of E-cadherin.

It has been reported that the M105I mutation affects the expression but not the function of the protein.