Sentence examples for mutation that restricts from inspiring English sources

First, inhibition of GTP hydrolysis by Sar1 using a mutation that restricts Sar1 to the GTP-bound state (Sar1H79G) causes transmembrane and soluble cargo to become accumulated in pre-budding complexes that often accumulate in the juxtanuclear region of mammalian cells; in contrast, GPI-anchored cargo remains restricted to the bulk of the ER (Stephens and Pepperkok 2004).

Consequently, we propose a simple algorithm to introduce proline mutations that restrict the conformational flexibility of CDRs and enhance the kinetics and affinity of immunoglobulin interactions.

In line with this mechanism, mutations that restrict the freedom of movement of the ubiquitin-fold domain decrease the efficiency of Ubl transfer onto the E2 [ 34, 38].

A flexible hinge region connecting the two HECT lobes enables this remarkable rearrangement, and mutations that restrict conformational freedom in this region inhibit the ubiquitylation activity of WWP1/AIP in vitro, attesting to the functional importance of structural flexibility in this enzyme [ 63].

Previous work suggested strain-background specific requirements for the Mps3 SUN domain, possibly due to mutations in factors that restrict Mps3 to the SPB (Rao et al. 2011).

It has been argued that the ocular defects are caused by a recent mutation that is restricted to horses that are related to the Rocky Mountain Horse breed.

It has been argued that these ocular defects are caused by a recent mutation that is restricted to horses that are related to the Rocky Mountain Horse breed.

Subsequent modifiers that restrict expression to the appropriate sex may result in fixation of the male beneficial mutation.

There are some areas that restrict prospecting.

That restricts Ms. Rosenfeld's options.

That restricts the mobility.