Sentence examples for mutation that restored from inspiring English sources

This mutation was, in fact, a reversion mutation that restored a wild-type lysine residue that had been mutated to a serine residue as part of a surface-entropy-reduction strategy aimed at enhancing the ability of the FN3 scaffold to form crystal contacts (Garrard et al., 2001 ).

Norquist et al (2011) observed similar findings in vivo, with ∼28% of recurrent tumours having a secondary mutation that restored BRCA1 or BRCA2 function.

Nevertheless, our in vitro studies of SpoIIE oligomerization combined with the unbiased isolation of a suppressor mutation that restored sporulation and oligomerization strongly suggest, we believe, a role for oligomerization in vivo.

These mutations can in turn induce selection pressure for mutations that compensate for these effects (called accessory mutations; e.g. a mutation that restores the protein stability).

A genetic screen was developed to identify suppressor mutations that restored catalytic activity in vivo from two kinase-dead Protein Kinase A mutants in S. cerevisiae.

This included mutations that restored Watson-Crick base pairing in 5 RNA stems: A5539G in tRNATrp; A5592G in tRNAAla; T7581C or G7521A in tRNAAsp; G1438A or T1452C in 12S rRNA; G3010A or T3027C in 16S rRNA gene.

Subsequent work has identified 'permissive' mutations that restored the fitness of these viruses [ 17].

The double mutations that restored base pairing (U110A A206U and U110C A206G) performed branching at a rate comparable to that of wild type.

Following mutagenesis of dms4-1 seeds using ethyl methanesulfonate (EMS), we retrieved four dominant intragenic suppressor mutations that restored DMS4 function and wild-type phenotypes.

Such a pattern of changes that involves multiple mutations could be explained by an initial deleterious mutation compensated by selection on subsequent mutations that restored the identity of the S residue.

Thus, during the first 3 years of the pandemic influenza A(H1N1), HA mutations that increased receptor binding avidity, followed by the selection of compensatory mutations that restored binding to the original levels were presented.