Sentence examples for mutation that reduced from inspiring English sources

The esterase activity that evolved in the presence of GroEL was far more efficient than that which could be obtained without GroEL because it depended upon a destabilizing mutation that reduced the rate of folding and greatly reduced enzyme activity in the absence of chaperonin buffering.

Firstly, the residue K138 (the only sole point mutation that reduced NF449 sensitivity) points away from the proposed ATP-binding site in the P2X1 receptor homology model.

All transductants showed the same low level of LacZ expression, suggesting that the mutation that reduced expression was not in or near the purR gene.

In a screen for zebrafish mutants with abnormal myelination, Pogoda et al. identified st51 as a mutation that reduced mbp expression in the CNS at 5 dpf (Pogoda et al., 2006).

In a genetic screen to identify genes that are required for the development of myelinated axons in zebrafish, st51 was discovered as a mutation that reduced myelin basic protein (mbp) mRNA expression in the CNS (Pogoda et al., 2006).

A mutation that reduces antiviral interferons underlies certain cases of severe influenza in children.

The Ago2V966M flies carry a point mutation that reduces the cleavage activity of Ago2 by eight-fold, but does not affect the expression levels of Ago2 [42].

These results illustrate how a mutation that reduces female fertility can concomitantly contribute to increase fecundity in a novel niche.

An A50I mutation that reduces the vinculin-talin interaction strength abolishes the FA stabilizing effect of these constructs.

Any mutation that reduces it in relation to the wild-type strain is said to carry a 'fitness cost'.

The Δ280K mutation is the only known MAPT mutation that reduces E10 inclusion and is associated with lesions containing exclusively, or, at least predominantly, 3R tau (22, 23).