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When an individual receives an antibiotic that specifically kills the bacteria causing the disease say, tuberculosis the immense majority of the bacteria die, but one in a million may have a mutation that provides resistance to the antibiotic.
Earlier reporting: For just the second time, a patient with AIDS appears to have been cured of the disease after receiving a stem cell transplant from a donor with a genetic mutation that provides resistance to HIV, which causes AIDS.
But, of course, as the mutant gene becomes more common, any insect that happens to have a mutation that provides a slightly higher tolerance for the defensive chemical will be favored, and over many generations, this gene will become more common in the insect population.
First, a mutation that provides the potential to metastasize might have other effects (pleiotropy) that increases the survival or reproductive potential of the clone and so compensates for the fitness penalty of cell emigration [2], [5].
Thus, the conserved serine residue may represent a "resistance mutation" that provides protection against naturally occurring antibiotics.
A driver gene is defined as a gene harboring a mutation that provides a selective advantage to the cancer cell.
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We found that homozygosity for the mutant allele leads to a marked loss of the protein levels of DJ-1 in fibroblasts in vivo and thereby confirm previous in vitro data on the E64D and the L166P mutation that provided evidence for instability of the mutant protein (supplemental figure S1) [8].
One of the hallmarks of cancers is their ability to accumulate mutations that provides progressive and survival advantages as well as resistance to cell death mechanisms.
The isolate described here, Pond1, contains a unique combination of mutations that provides a way to track the spread of this strain of S. Paratyphi A.
Whether sequence context determines adduct formation in specific codons in p53, that would account for the mutational spectra seen in human lung cancer, or whether this mutational spectra results from biological selection of those mutations that provide a growth advantage, remains controversial.
Cattle-herding peoples developed an ability to digest milk as adults through mutations that provided a definite survival advantage when times were hard.
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abnormality that provides
mutation that chokes
mutation that produces
mutation that disrupts
mutation that interferes
mutation that abolishes
mutation that closes
mutation that is
mutation that arises
mutation that lowers
mutation that helps
mutation that results
mutation that indicates
mutation that occurs
mutation that afflicts
mutation that creates
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com