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Here, we report the positional cloning of Ter, revealing a point mutation that introduces a termination codon in the mouse orthologue (Dnd1) of the zebrafish dead end (dnd) gene.
At codon 1956, we found a point mutation that introduces a premature stop codon, reducing the length of EAST protein from 2301 to 1955 amino acids.
In ePop, luxR* contains a frame-shift mutation that introduces an early stop codon and completely abolishes the luxR DNA-binding domain, as determined by homology to TraR [12].
A low magnitude of PFDs across 4 major SCOP classes confirmed the long-held myth of protein interior with low dielectric constant and explains why charge burial in the protein interior is so prohibitive and why a point mutation that introduces net charges or dipoles deep within the interior can destabilize the protein.
The D27L, E34F, R37A superclamp mutation that introduces hydrophobic residues in the CpxI accessory helix did not change the ability to rescue the complexin I-III KO phenotype.
p53[11-1B-1] is a point mutation that introduces a stop codon at nucleotide residue 211, and is predicted to yield a 70AA truncated protein ("M").
Similar(46)
A suppressor mutation that creates.
She has a gene mutation that caused tuberous sclerosis.
Jeff Carroll inherited the DNA mutation that causes Huntington's disease.
That led them to a tiny mutation that made all the difference.
"It has been very hard to find a mutation that abolishes aging," Dr. Rose said.
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