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It was a new mutation that had first appeared in Jim," says Karen.
The new mutation did not simply reverse the mutation that had originally turned the microbe's ancestors into cheaters.
Each control sample carried at least one mutation that had been previously validated by Sanger sequencing (see methodology section).
Dr. Schal said the next step was to figure out the details of the genetic mutation that had occurred.
The researchers' new discovery involves a gene called MYH16, which had apparently gone unrecognized because of a small mutation that had rendered it inactive for producing some jaw muscles for chewing and biting.
That meant telling the teenager about her own future risk — that she had a 50percentt chance of carrying a mutation that had already riddled their extended family — both male and female — with the disease.
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Poole also praised the "creative mutation" that has grown on both sites.
The fitness effects of these synonymous mutations thus resemble those of any other non-synonymous mutation that has been selected.
After filtering many candidates, he homed in on a gene mutation that has been associated with certain types of cancer but has never been associated with neuromuscular diseases.
That also means, Oxitec insists, that there is no danger of the mutation that has been introduced to the males from being passed down the generations.
I looked at the APOE gene report, which has a mutation that has been linked to Alzheimer's disease.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com